Concomitant usage of dihydrocodeine and sedative medicines like benzodiazepines or linked drugs may well result in sedation, respiratory depression, coma and Loss of life. Thanks to these risks, concomitant prescribing with these sedative medicines really should be reserved for patients for whom alternative treatment options are not possible. If a choice is made to prescribe dihydrocodeine concomitantly with sedative medicines, the bottom successful dose must be employed, plus the length of treatment really should be as short as possible (see also typical dose advice in section four.
The anticoagulant outcome of warfarin and other coumarins can be Improved by prolonged typical usage of paracetamol with greater possibility of bleeding; occasional doses have no significant result.
Ethanol Grapefruit Juice Tobacco Using this medicine with any of the following may well cause an increased chance of sure side effects but might be unavoidable in some instances.
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Abruptly stopping this medication may well result in withdrawal, particularly if you have utilized it for a long time or in high doses. To avoid withdrawal, your health practitioner may possibly decrease your dose bit by bit.
Sedative medicines such as benzodiazepines or associated drugs: The concomitant usage of opioids with sedative medicines like benzodiazepines or connected drugs increases the chance of sedation, respiratory depression, coma and Dying thanks to additive CNS depressant impact. The dose and length of concomitant use needs to be confined (see section four.4).
Patients need to be closely monitored for signs of misuse, abuse, or addiction. The scientific require for more info analgesic treatment really should be reviewed regularly.
In case you are pregnant or breast-feeding, Believe you could be Expecting, or are intending to have a infant, question your doctor or pharmacist for suggestions before taking this medicine.
The velocity of absorption of paracetamol might be amplified by metoclopramide and domperidone and absorption lowered by cholestyramine.
Warning must be taken when paracetamol is used concomitantly with flucloxacillin as concurrent intake has been associated with high anion gap metabolic acidosis, specifically in patients with risks aspects (see section 4.4).
When you take Dihydrocodeine tablets during pregnancy, your child might become dependent and encounter withdrawal symptoms following the beginning which may well need to be handled. Will not take Dihydrocodeine tablets while you are breast-feeding as dihydrocodeine passes into breast milk and can affect your infant.
If you purchase any medicines, check with a pharmacist that they're safe to take with an opioid painkiller.
There is actually a hazard of building serotonin syndrome with concomitant utilization of opioids and serotonergic medicine(s). The chance may differ depending on the medicine blend.
Before you begin the treatment, go through the manufacturer's printed information leaflet from inside the pack. It will give you more information about dihydrocodeine and may offer you with a full list of the side-effects which it's possible you'll working experience from getting it.